About

Web service URL Source code
ClinOmicsTrail https://clinomicstrail.bioinf.uni-sb.de -
DrugTargetInspector https://dti.bioinf.uni-sb.de -
GeneTrail2 https://genetrail2.bioinf.uni-sb.de C++ code for enrichment algorithms (https://github.com/unisb-bioinf/genetrail2)
NetworkTrail https://networktrail.bioinf.uni-sb.de C++ code for subgraph ILP (http://genetrail.bioinf.uni-sb.de/ilp/Home.html)
RegulatorTrail https://regulatortrail.bioinf.uni-sb.de -

ClinOmicsTrail

ClinOmicsTrail is an interactive visual analytics tool for multi-omics breast cancer data that provides rich functionality for the integrative analysis and visualization of these data sets. ClinOmicsTrail analyzes and integrates clinical markers with genomic and transcriptomic datasets, where genomic data sets can comprise mutations, copy number variations, or both. Based on the user-provided data, we provide several types of fully interactive visualizations that allow the user to (i) obtain a general overview on altered pathways and mechanisms especially relevant to breast cancer and to (ii) investigate single pathways or genes in detail and also in comparison to a set of reference breast cancer cell lines.

DrugTargetInspector

DrugTargetInspector (DTI) is an interactive assistance tool for treatment stratification. DTI analyzes genomic, transcriptomic and proteomic datasets and provides information on deregulated drug targets, enriched biological pathways and deregulated subnetworks, as well as mutations and their potential effects on putative drug targets and genes of interest. Please refer to our publication for further details and case studies (doi: 10.1002/ijc.29897).

GeneTrail2

GeneTrail2 is a web-interface providing access to different tools for the statistical analysis of molecular signatures. GeneTrail2 allows the integrated analysis of transcriptomic, miRNomic, genomic, and proteomic datasets. It offers multiple statistical tests, a large number of predefined reference sets, as well as a comprehensive collection of biological categories and enables direct comparisons between the computed results.

NetworkTrail

NetworkTrail is a web-interface providing access to different analysis tools for regulatory networks.

RegulatorTrail

RegulatorTrail is a web-interface providing access to different methods to identify and prioritize key transcriptional regulators with respect to their impact on expression changes caused e.g. by pathological processes. All methods are based on different statistical tests and make use of our comprehensive collection of position count matrices (PCMs) and regulator-target gene interactions (RTIs) extracted from a variety of databases.